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ORIGINAL ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 1  |  Page : 20-23

Prevalence of extended spectrum beta-lactamase-producing Klebsiella species at the University of Ilorin Teaching Hospital


1 Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria
2 Department of Medicine, University of Ilorin, Ilorin, Nigeria

Correspondence Address:
B U Faari
Departments of Medical Microbiology and Parasitology, University of Ilorin Teaching Hospital, PMB 1459, Ilorin
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/9783-1230.169059

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Background: Persistent blind antibiotic treatment of patients, in resource poor nations like Nigeria, makes the prevalence of antibiotic resistance to increase sporadically. Extended spectrum beta-lactamase (ESBL) production is one of the ways by which bacteria become resistant to antibiotics. For this reason, isolation, identification, sensitivity and screening for possible resistance genes is very important before prescription, if the affected patients must receive qualitative care particularly when their condition is chronic. Materials and Methods: Four hundred suspected isolates of Klebsiella belonging to various species obtained from routine specimens such as swabs, urine, blood, and sputum from May to October 2009 were studied. The identity of all isolates obtained was biochemically analyzed. The isolates were subjected to antibiotic susceptibility testing using modified Kirby–Bauer method and ESBL production was phenotypically determined using double disc synergy test for laboratory detection and reporting of bacteria by CLSI method. Results: Ninety-eight (24.5%) isolates expressed ESBL. Majority of the ESBL producing isolates were from swab specimens 59 (14.75%) followed by blood culture 16 (4.0%), urine 13 (3.25%), and sputum 10 (2.5%). Sensitivity patterns of ESBL producing Klebsiella spp. revealed that all ware resistant to augmentin (AUG), ceftazidime (CAZ), cefotaxime (CTX), cefuroxime (CRO), cefpodoxime (CPD), and none resistant to imipenem (IMP).Conclusion: ESBL producing Klebsiella spp., were present in University of Ilorin Teaching Hospital. They are resistant to augmentin (AUG), CAZ, CTX, and CPD. Presence of ESBL in any Klebsiella spp. has made cephalosporins which are first line antibiotics usually given non-effective, thereby reducing the treatment options. We, therefore, suggest screening and confirmation for ESBL, in other to prevent treatment failure.


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